Neurotransmitters, Receptors and Drug Action

Membrane receptors for hormones and neurotransmitters

Receptors for peptide hormones and neurotransmitters are integral components of the plasma membrane of cells which serve to couple the external milieu to the intracellular regulators of metabolism. These macromolecules are usually high molecular weight glycoproteins, and in many cases appear to have more than one subunit capable of binding the hormone. The interaction of the hormone or neurotra...

Receptors for neurotransmitters and peptide hormones.

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گیرنده های داروئی ( Drug Receptors )

Neurotransmitters and Their Receptors in the Rat Superior Cervical Ganglion

The superior cervical ganglion (SCG), the sympathetic organ innervating the carotid body (CB), lies at the bifurcation of the common carotid artery, near the CB. The ganglion is composed of functional subsets of neurons showing different sympathetic phenotypes. The expression of putative neurotransmitters and their receptors in the rat SCG was investigated at light microscopical level using imm...

NMDA receptors as targets for drug action in neuropathic pain.

Hyperalgesia and allodynia following peripheral tissue or nerve injury are not only due to an increase in the sensitivity of primary afferent nociceptors at the site of injury but also depend on NMDA receptor-mediated central changes in synaptic excitability. Functional inhibition of NMDA receptors can be achieved through actions at different recognition sites such as the primary transmitter si...